Differential diagnosis of solitary pulmonary nodule: what does CT-perfusion give?

Silanteva N.K., Petrosian A.P., Kaprin A.D., Ivanov S.A., Usacheva A.Yu., Mozerov S.A., Kupriyanova E.I.

Рurpose. Evaluation of the CT-perfusion for the differential diagnosis of solitary pulmonary nodule. Materials and methods. In the Department of computed tomography A. Tsyb Medical Radi-ological Research Center CT-perfusion was performed in 20 patients (men – 14, women – 6; aged 34 to 79) with a solitary pulmonary nodule. CT study was performed on a multispiral computer tomography GE Optima CT660. Processing of the obtained CT-data was performed at the Advantage Workstation 4.6 (GE Medical Systems, USA). CT data were verified by com-parison with histological findings obtained after CT-guided transthoracic trepan biopsy. Results. The average rate of blood flow in adenocarcinomas was 172.5±83.2 ml/100g/min, blood volume 12.0±5.3 ml/100g, the permeability surface 24.7±7.2 ml/100g / min, the mean transit time 8.8±3.1 seconds. The average rate of blood flow in the nodule of pneumonia was 414.2±191.9 ml/100g/min, blood volume 19.3±8.5 ml/100g, permeability surface 32.9±30.4 ml/100g / min, the mean transit time 2.8±0.7 seconds. Conclusion. CT-perfusion is a new tool for the assessment of microcirculatory disor-ders in various processes, including in the lungs. However, the results obtained in this study are not always pathogenetic and are not always comparable among different researchers.

A. Tsyb Medical Radiological Research Centre – Part of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk, Russia

 

Keywords: nodule, differential diagnosis, computed tomography.

 

Corresponding author: Petrosian A.P., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript , тел.: +7 (953) 316-24-641, ORCID: 0000-0002-7663-0362.

For citation:Silanteva N.K., Petrosian A.P., Kaprin A.D., Ivanov S.A., Usacheva A.Yu., Mozerov S.A., Kupriyanova E.I. Differential diagnosis of solitary pulmonary nodule: what does CT-perfusion give? REJR 2018; 8(4):83-94. DOI:10.21569/2222-7415-2018-8-4-83-94.

Received: 14.09.18 Accepted: 10.10.18