Scintigraphic diagnosis of transthyretin cardiac amyloidosis (clinical case demonstration)

Ryzhkova D.V., Makurova T.V., Kozlenok A.V., Mitrofanova L.B.

Purpose. Demonstration and description of the rare clinical case of transthyretin cardiac amyloidosis.
Federal Almazov Medical Research Centre. Saint-Petersburg, Russia.



 

 

 

 

 

 

 

 

 

Materials and methods. Patient, 61-year-old was admitted to the clinic with exertional dyspnea. History of hypertension and aortic stenosis made it difficult to carry out differential diagnosis of accumulation disease. Patient underwent comprehensive complex investigation including echocardiography, scintigraphy with 99mTc-pyrophosphate, endomyocardial biopsy and genetic analysis. Results. Diagnosis of transthyretin cardiac amyloidosis was based on the high ac-cumulation level of 99mTc-pyrophosphate in the myocardium of left and right ventricles. Immunohistochemistry and molecular genetic analysis have confirmed the supposed diag-nosis. Conclusions. 99mTc-labeled pyrophosphate scintigraphy is an effective non-invasive diagnostic method that allows to identify ATTR cardiac amyloidosis.

 

Keywords: transthyretin cardiac amyloidosis; scintigraphy; 99mTc- pyrophosphate; endomyocardial biopsy.

 

Corresponding author: Ryzhkova D.V., Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: : Ryzhkova D.V., Makurova T.V., Kozlenok A.V., Mitrofanova L.B. Scintigraphic diagnosis of transthyretin cardiac amyloidosis (clinical case demonstration). REJR. 2017; 7 (1):-. DOI:10.21569/2222-7415-2016-6-2-91-96.

Received: 19.01.2017Accepted:30.01.2017