Features of activation of the default mode network in people with a high level og chronic stress.

Zashezova M.Kh., Ustyuzhanin D.V., Kaverina A.R., Shariya M.A., Konovalov R.N., Ternovoy S.K.

Purpose. To study the nature of activity of the default mode network (DMN) of the brain according to resting state fMRI (rs-fMRI) data in people with high level of chronic stress. Materials and methods. The study involved 45 people aged from 25 to 77 years. Ac-cording to the results of psychological testing, participants were divided into two groups: with high and low levels of chronic stress. Resting state fMRI was performed on a magnetic resonance scanner Philips Achieva 3.0T. To process the data obtained, statistical programs GIFT v2.0, SPM8 based on MatLab7.4. To view and present the data received, we used the xjView 8.4 application based on SPM8. Results. Statistically significant differences in the patterns of neuronal activation of DMN in the groups of people with high and low levels of chronic stress were revealed. The zones of decreased activity of DMN in people with high level of chronic stress were determined in the region of the right and left precuneus, the gyrus cinguli and lobulus parietalis inferior of the left hemisphere. The zones of increasing activity of DMN in people with high level of chronic stress were determined in the region of the right lobulus paracentralis, right and left gyrus frontalis medialis, right and left gyrus temporalis medius. Conclusions. The results of the study made it possible to identify areas of decline and increase of spontaneous neuronal activity in people with high level of chronic stress. The change in neuronal activity in the zones included in DMN in people with chronic stress may indicate a change in functional connectivity and reflect the phenomenon of brain neu-roplasticity, which is aimed at optimizing neuronal connections in response to chronic stress. urpose. To study the nature of activity of the default mode network (DMN) of the brain according to resting state fMRI (rs-fMRI) data in people with high level of chronic stress. Materials and methods. The study involved 45 people aged from 25 to 77 years. Ac-cording to the results of psychological testing, participants were divided into two groups: with high and low levels of chronic stress. Resting state fMRI was performed on a magnetic resonance scanner Philips Achieva 3.0T. To process the data obtained, statistical programs GIFT v2.0, SPM8 based on MatLab7.4. To view and present the data received, we used the xjView 8.4 application based on SPM8. Results. Statistically significant differences in the patterns of neuronal activation of DMN in the groups of people with high and low levels of chronic stress were revealed. The zones of decreased activity of DMN in people with high level of chronic stress were determined in the region of the right and left precuneus, the gyrus cinguli and lobulus parietalis inferior of the left hemisphere. The zones of increasing activity of DMN in people with high level of chronic stress were determined in the region of the right lobulus paracentralis, right and left gyrus frontalis medialis, right and left gyrus temporalis medius. Conclusions. The results of the study made it possible to identify areas of decline and increase of spontaneous neuronal activity in people with high level of chronic stress. The change in neuronal activity in the zones included in DMN in people with chronic stress may indicate a change in functional connectivity and reflect the phenomenon of brain neu-roplasticity, which is aimed at optimizing neuronal connections in response to chronic stress.
1 - Russian Cardiology Research and Production Complex, Ministry of Health of Russia.
2 - Lomonosov Moscow State University
3 - Center of Neurology, Russian Academy of Sciences.
4 - Sechenov First Moscow State Medical University. Moscow, Russia.


 

 

 

 

 

 

Keywords: resting state fMRI, functional connectivity, rest networks, default mode network, chronic stress.

 

Corresponding author: Zashezova M.Kh., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Zashezova M.Kh., Ustyuzhanin D.V., Kaverina A.R., Shariya M.A., Konovalov R.N., Ternovoy S.K. Features of activation of the default mode network in people with a high level og chronic stress. REJR. 2017; 7 (3):31-39. DOI:10.21569/2222-7415-2017-7-3-31-39.

Received: 30.06.2017 Accepted: 28.08.2017