Visualization of brain changes in the patient with acute lymphoblastic leukemia.

Bondarenko V.P., Tereschenko G.V., Andrianov M.M., Zhukovskaya E.V.

Purpose. To evaluate the role of premorbid conditions in development of isolated central nervous system (CNS) relapse in a patient with acute lymphoblastic leukemia (ALL) in remission, to describe radiologic features of optic nerve leukemic lesion in this patient. Materials and methods. MRI of the brain was performed in a boy of 9 years, with ALL, at three stages: during the prevention of relapse, immediately after the manifestation of symptoms (remission period) and after transplantation of hematopoietic stem cells. The study was carried out using GE Optima 360 1.5T and Philips Achieva 3T machines. The analysis of domestic and foreign literature was also carried out. Results. An isolated CNS relapse developed in a patient with typical MR-features of post-chemotherapeutic leukoencephalopathy and intracerebral hemorrhages. The infiltration of retina (optic disk) was revealed. After the anti-relapse therapy, there was no evidence of the brain tumor. Diffuse changes in white matter - without dynamics. Conclusion. MR-features of this patients with ALL, complicated by neuroleukemia, dictate the need to study the role of premorbid pathomorphologhical changes of CNS in de-velopment of neuroleukemia.

IDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology. Moscow, Russia.

 

 

 

 

 

Keywords:neuroradiology, neuroleukemia, oncohematology, CNS relapse, optic nerve, leukoencephalopathy.

 

Corresponding author:Bondarenko V.P., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Bondarenko V.P., Tereschenko G.V., Andrianov M.M., Zhukovskaya E.V. Visualization of brain changes in the patient with acute lymphoblastic leukemia. REJR 2017; 7(3):176-182. DOI:10.21569/2222-7415-2017-7-3-176-182.

Received: 19.05.2017 Accepted:17.07.2017