The Informativeness Of Radionuclide Renoscintigraphy And Biochemical Markers In The Detection Of Renal Dysfunction In Patients With Coronary Artery Disease Who Underwent Myocardial Revascularization

Vesnina Zh.V., Arsenjeva Yu.A., Lishmanov Yu.B.

Purpose. To evaluate the diagnostic significance of radionuclide renoscintigraphy and biochemical markers in the detection of renal dysfunction in patients with coronary artery disease (CAD) in the early postoperative period after coronary artery bypass grafting (CABG). Materials and methods. The randomized, controlled trial was performed in 108 CAD patients (all men, mean age 54.94 ± 0.72 years) undergoing CABG. All patients underwent dynamic renal scintigraphy with 99mТс-DTPA and were subjected to measuring the concen-tration of creatinine, lipocalin (NGAL) and Cistatin C in blood serum before and after CABG. Results. After CABG the mean values of total GFR and GFR for each kidney signifi-cantly decreased and significant increases in the concentrations of NGAL and Cystatin С in blood serum were occurred. In the postoperative period the creatinine clearance also signifi-cantly decreased. Statistical analysis revealed direct correlation between the duration of ar-tificial circulation and the changes in GFR (R = 0.42; P = 0.017) and the levels of s-NGAL (R = 0.39, P = 0.02) in cardiac surgery patients. Conclusion. Radionuclide method is not inferior to its diagnostic value and informa-tiveness than biochemical markers in the evaluation of early postoperative renal dysfunction.
Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences. Tomsk, Russia.


 

 

 

 

 

 

Keywords:dynamic renoscintigraphy, lipocalin, Cistatin С, renal dysfunction, coronary artery bypass grafting.

 

Corresponding author:Vesnina Zh.V., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript .

 

For citation: Vesnina Zh.V., Arsenjeva Yu.A., Lishmanov Yu.B. The informativeness of radionuclide renoscintigraphy and biochemical markers in the detection of renal dysfunction in patients with coronary artery disease who underwent myocardial revascularization. REJR 2017; 7(4):65-73. DOI:10.21569/2222-7415-2017-7-4-65-73.

Received: 19.10.2017 Accepted:15.11.2017