Original articles gadolinium deposition in cerebral tissue after intravenous injection of linear type contrast agent
Syrkashev E.M., Bychenko V.G., Sinitsyn V.E.
| P urpose. To estimate degree of gadolinium deposition in brain structures among patients with multiple injections of linear type gadolinium-based contrast agents. Materials and methods. Retrospective study included 197 patients who received more than two studies with Gadodiamidum injection (0.2 ml/kg) from 2008 to 2017. The control group consisted of 7 patients who had performed at least two studies with no contrast agent injec-tion. |
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Results. Statistical analysis revealed positive correlation between globus palli-dus/thalamus signal intensity ratio and the number of previous studies with contrast injec-tion (r = 0.145, p = 0.042), with time period between the first and the last study (r = 0.222, p = 0.002) and with the age of patients (r = 0.145, p = 0.042). For nuclei dentati/pons ratio posi-tive correlation was revealed only with the number of previous studies with contrast injection (r = 0.172, p = 0.016). Conclusions. High signal intensity in globus pallidus and nuclei dentati on unen-hanced T1-images related with the number of contrast injection.
Keywords: gadolinium deposition, linear type gadolinium-based contrast agent, gadodiamidum, magnet-ic resonance imaging
Corresponding author:Syrkashev E.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript
For citation: Syrkashev E.M., Bychenko V.G., Sinitsyn V.E. Gadolinium deposition in cere-bral tissue after intravenous injection of linear type contrast agent. REJR 2018; 8 (3):113-121. DOI:10.21569/2222-7415-2018-8-3-113-121.
Received: 01.07.18 Accepted:19.07.18