New possibilities of processing the results of lungs radiological studies

New possibilities of processing the results of lungs radiological studies

Zolotnitskaia V.P., Tishkov A.V., Agaphonov A.O., Strach L.V., Amosova O.V.

Microcirculation disorders play an important role in the pathogenesis of the development of lung diseases, determining the clinical course and progression of the pathological process, so a detailed analysis and quantification of blood flow disorders are an important tool for intravision.

Purpose. To create method for quantitative determination of impaired microcirculation in the lungs, calculation of perfusion deficiency and assessment of changes in the dynamic observation of patients during radionuclide techniques (perfusion scintigraphy and SPECT).

Material and methods. A quantitative calculation of the accumulation of radiopharmaceuticals in the lungs was carried out in 22 healthy patients, in 117 patients with stage 1-4 COPD (GOLD 2017), in 16 patients with histiocytosis X, in 11 patients with lymphocytosis, in 12 patients with pneumonia, in 8 patients with lung tumors and in 10 patients with other lung diseases. As examples, the study presents cases in patients with histiocytosis X, lung cancer and pneumonia. In the study, the results of MSCT were evaluated using high-resolution and functional CT techniques, and changes in the microcirculation in the lungs were evaluated when conducting research on a two-detector gamma camera Philips Forte 2005 (USA). A quantitative calculation of perfusion changes was performed using the developed LungScintAnalyser computer program.

Results. The study identified and quantified in the automatic mode changes in microcirculation in patients with lung diseases before and after surgical interventions, as well as after therapeutic treatment.

Conclusion. The developed technique of automatic processing of results of radiological lungs studies in comparison with the normal lungs is optimal for a variety of diseases. It allows to quantify microcirculation disorders and calculate the perfusion deficit, which is necessary when assessing the severity, dynamics of the pathological process and the effectiveness of the therapy.

 

I.P. Pavlov First Saint-Petersburg Federal State Medical University

Saint-Petersburg, Russia

 

Keywords: microcirculation, SPECT, pneumonia, histiocytosis X, lung cancer.


Corresponding author:  Zolotnitskaia V.P., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript .

 

For citation: Zolotnitskaia V.P., Tishkov A.V., Agaphonov A.O., Strach L.V., Amosova O.V. New possibilities of processing the results of lungs radiological studies. REJR 2019; 9(2):98-106. DOI:10.21569/2222-7415-2019-9-2-98-106.

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Received:        15.05.19 Accepted:       14.06.19