Resting state functional MRI. General issues and clinical application

Bukkieva Т.А., Chegina D.S., Еfimtsev А.Yu., Levchuk A.G., Iskhakov D.K.,

Sokolov A.V., Fokin V.A., Trufanov G.E.

Purpose. Possibilities of visualization not only of the anatomical changes of the brain, but also of its functioning in normal conditions and under various pathological conditions is one of the main tasks of modern neuroradiology. The main method of neuroimaging, which allows to evaluate the functional activity of various areas of the brain, is Magnetic resonance imaging (MRI). The MRI technique, which can be performed using the stimulus paradigm or at rest, is called functional MRI (fMRI). FMRI at rest (resting state fMRI, rs-fMRI) is a unique technique that allows you to evaluate the basic activity of the brain in the absence of sensory or cognitive stimuli. This technique opens up possibilities for studying the so-called functional connectivity of the brain, which is represented as connections between different parts of the brain with the formation of working «resting state networks». In this review we examine the principle of rs-fMRI, consider the basic methods of analyzing functional connectivity, their advantages and disadvantages, and also give a brief overview of the use of rs-fMRI in various diseases. 

Almazov V.A. National medical research center

Saint-Petersburg,

Russia

 

Keywords: fMRI, resting state fMRI, brain networks.


Corresponding author: Bukkieva T.A., e-mail:  Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Bukkieva Т.А., Chegina D.S., Еfimtsev А.Yu., Levchuk A.G., Iskhakov D.K.,Sokolov A.V., Fokin V.A., Trufanov G.E. Resting state functional MRI. General issues and clinical application. REJR 2019; 9(2):150-170. DOI:10.21569/2222-7415-2019-9-2-150-170.

Received:        14.05.19 Accepted:       14.06.19