Influence of risk factors identified on СT and MRI on the treatment tactics in patients with neck neuroblastoma

Ternovaya E.S., Rubtsova N.A., Kachanov D.Yu., Shamanskaya T.V., Varfolomeeva S.R., Tereshchenko G.V.

Purpose. The study aimed to evaluate clinical role of CT and MRI in staging of patients with cervical neuroblastoma (NB) and influence of the imaging modalities on choice of optimal timing and volume of surgical resection

Materials and methods. Data of 10 patients with histologically proven cervical NB admitted to Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology between 2013-2017 was analyzed.. All cases underwent CT scans and MRI for diagnosis and post-chemotherapy follow-up. Operation notes were analyzed for surgical radicality and timing of the surgical treatment. CT and MRI imaging reports were reviewed for Image Defined Risk Factors (IDRF).

Results. Prevelance of cervical NB was 2,2% (out of 449 cases). 7 children had positive IDRF. L2 stage was found in 40%, stage M in 30%, MS in 20% and L1 in 10%. Complete resection was possible in all patients without any IDRF and in 1 patient with IDRF. 6 patients had biopsy after initial diagnosis. 2 patients have undergone surgical treatment after pre-operative chemotherapy.

Conclusion. СТ and MRI are valuable imaging techniques for accurate pretreatment staging of patients with NB. IDRFs help establish best timing and optimal extent of surgical treatment in patient with neuroblastoma.

1 - Dmitry Rogachev National Research

Center.

2 - P.A. Herzen Moscow Cancer Research

Institute.

3 - N.N. Blokhina National Medical Research Center for Oncology. Moscow, Russia.

 

Keywords: neuroblastoma, image defined risk factors, IDRF, pediatrics, INSS, INRGSS.

 


Corresponding author:  Ternovaya E.S., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Ternovaya E.S., Rubtsova N.A., Kachanov D.Yu., Shamanskaya T.V., Varfolomeeva S.R., Tereshchenko G.V. Influence of risk factors identified on СT and MRI on the treatment tactics in patients with neck neuroblastoma. REJR 2019; 9(4):43-55. DOI:10.21569/2222-7415-2019-9-4-43-55.

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Received:        11.10.19 Accepted:       28.10.19