18F-fluorodeoxyglucose PET/CT in diagnostics of infective endocarditis of native valve

18F-fluorodeoxyglucose PET/CT in diagnostics of infective endocarditis of native valve

Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Katunina T.A., Serguladze S.Yu., Muratov R.M., Mironenko V.A.

Purpose. To investigate the diagnostic performance of 18F-fluorodeoxyglucose PET/CT in patients with infective endocarditis of native valve (IENV).

Material and methods. The analysis included results of PET/CT examinations performed in 15 patients with fever of unknown origin and intraoperatively confirmed (n=13) or excluded (n=2) IENV. Patients underwent PET/CT for suspected infectious process: IENV (n=9), IE of prosthetic valve (n=3), IE of implantable intracardiac device (n=2), aortic prosthesis infection (n=1). PET/CT scan was performed 90 min after intravenous injection of 18F-FDG (175-200MBq). All patients underwent carbohydrate-free diet and fasted for at least 15-18 hours.

Results. Overall, PET/CT results correctly confirmed the infection in NV in 31%(4/13) and ruled it out in 50%(1/2) of patients. Thus, in the analyzed group (n=15), the sensitivity, specificity and diagnostic accuracy of PET/CT in IENV diagnosis were 31%, 50% and 33%, respectively; positive and negative predictive value – 80% and 10%.

In 62%(8/13) of patients with confirmed IE, whole body PET/CT revealed other than NV previously unknown foci of inflammation: in the area of aortic valve prostheses (n=2), in the lung (n=1), in the lung and along the pacemaker (n=2), along the ascending aorta prosthesis (n=1), in the lumbar vertebra (spondylodiscitis) and in the lung (n=1), in the sternum (osteomyelitis) and in the right paraclavicular soft tissue component (n=1).

Conclusion. According to initial results, 18F-FDG PET/CT showed low sensitivity in the diagnosis of IENV – negative result in the NV area does not exclude the diagnosis. PET/CT is useful in the detection of extracardiac foci of inflammation..

A.N. Bakulev Scientific Center for

Cardiovascular Surgery of the Ministry of Health of the Russian

Federation.

Moscow, Russia.

 

Keywords: PET/CT, 18F-FDG, 18F-fluorodeoxyglucose, infectious endocarditis, native valve.


Corresponding author:  Pursanova D.M., e-mail: Этот e-mail адрес защищен от спам-ботов, для его просмотра у Вас должен быть включен Javascript

 

For citation: Aslanidis I.P., Pursanova D.M., Mukhortova O.V., Shurupova I.V., Katunina T.A., Serguladze S.Yu., Muratov R.M., Mironenko V.A. 18F-fluorodeoxyglucose PET/CT in diagnostics of infective endocarditis of native valve. REJR 2019; 9(4):68-76. DOI:10.21569/2222-7415-2019-9-4-68-76.

.

Received:        06.09.19 Accepted:       14.10.19